Liver cirrhosis
Conditions
Interventions
Ligation group:Esophagogastric varices were treated with a lasso, starting from the farthest end of the varices of the gastric fundus and spiraling to the side of the esophageal opening.
Combined treatment group:The gastric varices were treated by injection with sclerosing agent combined with tissue glue, and the esophageal varices were treated by ligation device.
Sponsors
Shenzhen Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1)18-70 years old (2) Liver cirrhosis was complicated with severe esophageal varices extending to the lesser curvature of the stomach, and the diameter of the gastric varices was =1.0cm (3) Endoscopic emergency treatment of esophageal and gastric variceal hemorrhage or secondary prevention of esophageal and gastric variceal hemorrhage (4) Agree to participate in the study and sign the informed consent
Exclusion criteria
Exclusion criteria: (1) With advanced primary liver cancer, secondary liver cancer or other malignant tumors, the expected survival time is not more than half a year (2) Combined with non-GOV1 gastric varicose veins, ectopic varicose veins or active peptic ulcer (3) Varicose veins too thick can not be ligation treatment (4) Important diseases of heart, lung, brain and kidney, including stroke, uremia, acute coronary syndrome, respiratory insufficiency or type I hepatorenal syndrome, and grade 2-4 hepatic encephalopathy (5) Inability to tolerate endoscopy and treatment (6)TBil>170umol/L or Child-Pugh>13 points (7) No patients with cirrhosis (8) Patients who had been treated with sclerosing agent, tissue glue or ligation before enrollment and the ulcer had not healed after treatment (9) Patients allergic to rubber, propofol or tissue glue
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether the patient had esophageal varices rupture and bleeding within 6 weeks after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Whether the patient underwent surgical disconnection/shunt/liver transplantation /TIPS within 6 weeks after surgery;Whether the patient died within 6 weeks after surgery and the cause of death;The severity of endoscopic esophageal varices was evaluated 6 weeks after surgery;Changes of blood routine and liver and kidney function of patients; | — |
Countries
China
Contacts
Public ContactAnjiang Wang
Shenzhen Hospital of Southern Medical University
Outcome results
None listed