Polycystic ovarian syndrome
Conditions
Interventions
Intervention group:Lactobacillus acidophilus+melbine (DMBG)
Sponsors
Reproductive Center, the Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Patients with PCOS with obesity (BMI >= 28kg/?) and insulin resistance index (HOMA-IR) greater than or equal to 2.69; 2. Women of childbearing age, aged 18-40 years; 3. No drugs affecting menstruation (such as contraceptives, hormones or other drugs affecting insulin, blood sugar, sex hormones and lipid metabolism) were taken within 3 months, and no related treatment was used, and no induced abortion was recorded; 4. Gynecological examination and auxiliary examination: there are no organic lesions in the internal and external genitalia, and there are no other primary diseases; 5. Those who have signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with other endocrine diseases, such as diabetes, thyroid disease, secreting sex hormone tumors, etc; 2. Physical diseases associated with severe or unstable states, including diseases of the liver, kidney, cardiovascular, respiratory, nervous or blood system, autoimmune diseases, etc., psychiatric patients; 3. Have a history of thromboembolic disease or a tendency to thrombosis; 4. Women who smoke or drink heavily; 5. Lactating or pregnant women; 6. Women with a history of other malignant tumors; 7. Use of statins/antibiotics/Lactobacillus acidophilus products/Chinese medicines/antiandrogens/insulin sensitizers or other drugs known or suspected to affect reproductive or metabolic function within the last 3 months; 8. Special physique, allergic to drugs; 9. Patients who need to be treated in other aspects in addition to the disease, which affects the study and cannot be carried out according to the study protocol; 10. There are congenital deficiencies in the reproductive system that cannot meet the needs of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance;Six items of sexual hormones; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Menstrual cycle;Height and weight; | — |
Countries
China
Contacts
Public ContactLiu Zhaoxia
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed