PRP combined with autologous hamstring tendon reconstruction for primary ACL injury: a multicenter, prospective, randomized controlled study

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076219

Enrollment

Unknown

Registered

2023-09-27

Start date

2023-09-30

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACL injury

Interventions

experimental group:The patient received a total of two PRP treatments. The first intraoperative treatment was LP-PRP, and the specific method was to prepare PRP gel (4ml) and inject it into the bone t

control group:There was no PRP intervention during or after operation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The primary ACL injury is diagnosed. 2. Age: 18-50 years old, can be combined with meniscus injury; 3. Willing to undergo autogenous hamstring tendon ACL reconstruction; 4. Willing to participate in this clinical trial and accept follow-up; 5. Indications for ACL reconstruction surgery: According to the Evidence-Based Guidelines for Clinical Diagnosis and Treatment of Anterior cruciate Ligament Injury (2022 edition), combined with the actual situation of this study, the specific surgical indications are: clear ACL injury with repeated knee instability; Combined with meniscus injury; Want to return to the swerve and stop type of exercise; Young patients with no need to return to exercise, but with complete ACL rupture and obvious knee instability.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. Diagnosis combined with other ligament or cartilage injury; 2. History of ipsilateral knee injury and surgery; 3. Associated with other arthritic diseases; 4. Combined with definite knee osteoarthritis (K-L? and above, Outerbridge? and above); 5. Systemic infection, local joint infection and other contraindications of surgery and PRP treatment; 6. Combined with type 2 diabetes.

Design outcomes

Primary

Measure	Time frame
Lysholm score for knee function assessment;MRI Mapping;IKDC score of knee function assessment;Tegner score for knee function assessment;Knee pain score VAS score;Knee range of motion;	—

Secondary

Measure	Time frame
CT Mapping;X ray;Overall quality of life score:EQ-5D score;Overall Quality of Life score WOMAC score;	—

Countries

China

Contacts

Public ContactLi Jian

West China Hospital, Sichuan University

18980601388@163.com+86 189 8060 1388

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026