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Study on the molecular mechanism of mast cell-mediated neuroinflammation leading to atopic dermatitis ADHD

Study on the molecular mechanism of mast cell-mediated neuroinflammation leading to atopic dermatitis ADHD

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300076215
Enrollment
Unknown
Registered
2023-09-27
Start date
2023-10-01
Completion date
Unknown
Last updated
2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis

Interventions

AD patients with ADHD:no
AD patients without ADHD:no

Sponsors

Chongqing Medical University Affiliated Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) Age: 6-18 years old; (2) AD combined with ADHD patients. Atopic dermatitis diagnosed according to Williams criteria or modified Williams criteria: with a history of skin itching for at least 1 month, plus 3 or more of the following: a. a history of skin involvement on the flexor side, including the cubital fossa, knee fossa, anterior ankle, or neck; b. A personal history of asthma or allergic rhinitis, or a history of atopic dermatitis in children under the age of 4 in first degree relatives; c. A history of dry skin throughout the body; d. Eczema can be seen on the flexed side or on the cheeks, forehead, and distal limbs of children under 4 years old; Disease onset before the age of 5.2 (not applicable to children under 4 years old). Attention Deficit Hyperactivity Disorder Diagnosed by DSM-5: A. Meets 6 or more persistent symptoms of attention deficit or hyperactivity impulse for 6 months; B. Several attentional disorders or hyperactive impulsivity symptoms already exist before the age of 12; C. Several attentional disorders or hyperactive impulsivity symptoms exist in two or more occasions (such as at home, school, or work; in activities with friends or relatives, in other activities); D. There is clear evidence that symptoms interfere with or reduce the quality of social, academic, or professional functions; E. Symptoms are not caused by schizophrenia or other psychiatric disorders, nor can they be explained by other mental disorders (such as mood disorders, anxiety disorders, separation disorders, personality disorders, substance poisoning, or withdrawal) (3) The guardian has signed an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Individuals with severe heart, lung, liver, kidney and other organ and systemic diseases; (2) Those who have recently used systemic immunosuppressive therapy (such as glucocorticoids); (3) Other diseases characterized by atopic dermatitis and skin lesions; (4) Individuals with systemic symptoms; (5) According to the researcher's judgment, guardians are unreliable or have poor compliance.

Design outcomes

Primary

MeasureTime frame
The Scoring Atopic Dermatitis(SCORAD) score;Pruritus score;SNAP-IV;

Countries

China

Contacts

Public ContactXiaoyan,Luo

Chongqing Medical University Affiliated Children's Hospital

xyluo@hospital.cqmu.edu.cn+86 130 1238 1671

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026