amnestic mild cognitive impairment
Conditions
Interventions
task training and paired stimulation:memory training with paired stimuli in the prefrontal-posterior parietal circuits
task training and singel-target stimulation:memory training with single-target stimuli in the prefrontal cortex
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. A diagnosis of aMCI, with no previous treatment for improving cognitive function; 2. Aged 50-80 years old, no gender limitation, right-handed; 3. Cognitive complaints and objective evidence (neuropsychological scale assessment); 4. > 6 years of education; 5. Provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Cancer, severe cardiac, hepatic, renal, circulatory, or infectious dysfunction; 2. History of neurological disease which could cause dementia, such as cerebrovascular disease and Parkinson's disease; 3. History of anxiety, depression, schizophrenia and other mental illness; 4. Severe hearing or visual impairment; 5. Contraindications to MRI (e.g., pacemakers, heart stents, artificial heart valves, fixation plates after fracture surgery, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test Part 5; | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral indicators: comprehensive neuropsychological tests, Hamilton Anxiety and Depression Scale, and assessment of daily living ability;Imaging indicators: functional and structural indicators; | — |
Countries
China
Contacts
Public ContactJie Ma
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed