Asthma
Conditions
Interventions
GINA Step-up Group:The treatment was up-steped according to GINA
GINA Step-down Group:The treatment was down-steped according to GINA
Sponsors
West China Hospital,Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for asthma; 2. Aged 18-70 years old; 3. Stable asthma, that is, no change in maintenance treatment plan, no respiratory infection or acute asthma attack within 4 weeks before enrollment; 4. No use of systemic glucocorticoids 4 weeks before enrollment; 5. Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Any asthma medications included in GINA step therapy had been used at the time of screening; 2. Accompanied by other respiratory diseases (such as chronic obstructive pulmonary disease, pneumonia, pulmonary fibrosis, bronchiectasis, tuberculosis, etc.), chronic diseases of the immune system, malignant tumors, uncontrolled severe hypertension, heart disease, severe diabetes, etc. 3. Patients who had undergone heart, lung or thoracic surgery; 4. Current smokers or smoking =15 pack-years; 5. Pregnant or lactating women; 6. With a history of alcohol and drug abuse; 7. Unable to cooperate with sputum induction, pulmonary function test or questionnaire survey.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma exacerbation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Asthma control;Pulmonary function;Airway and systemic inflammation;Transcriptomics, Metabolomics;Health Economics Indicators; | — |
Countries
China
Contacts
Public ContactZhang Xin
West China Hospital,Sichuan University
Outcome results
None listed