Senile Dementia
Conditions
Interventions
Normal treatment group:Administer Donegozil Hydrochloride Tablets (Anlishen), 5mg/d, orally.
Decoction group:On the basis of the normal treatment group, Wuzhi Maotao Hongzao Tang was given, and 3 bottles (300 mL/bottle) were consumed daily.
Sponsors
South China Hospital of Shenzhen University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Meets the NIA-AA diagnostic criteria for dementia; (2) Age range from 60 to 85 years old, regardless of gender; (3) Those with moderate (CDR=2.0) and severe (CDR=3.0) dementia according to CDR; (4) The scores of the Simple Intelligence Mental Inventory (MMSE) were: illiteracy<17 points, primary school education<20 points, and secondary school and above education<24 points; (5) Informed consent and voluntary cooperation with this trial.
Exclusion criteria
Exclusion criteria: (1) Those who do not meet the above diagnostic criteria and inclusion criteria; (2) There are other diseases that may cause cognitive impairment; (3) Other neurological diseases that may have been related to cognitive impairment in the past; (4) Patients who cannot fully cooperate and complete the examination; (5) Patients with concomitant mental system diseases; (6) Long term use of drugs to improve cognitive function, as well as the impact of alcohol and drug abuse on efficacy evaluation; (7) Patients who are intolerant or allergic to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination;MoCA;Clinical Dementia Rating;NPI Scale;Activity of Daily Living Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| gut microbe; | — |
Countries
China
Contacts
Public ContactNan Liu
South China Hospital of Shenzhen University
Outcome results
None listed