chronic kidney disease
Conditions
Interventions
Yi-Shen-Hua-Shi treatment group:Receive regular RAAS inhibitor in combination with Yi-Shen-Hua-Shi (1 bag three times daily) for 4 months
control group:Receive regular RAAS inhibitor
Sponsors
Department of Nephrology, Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: ? Patients aged 18-70 years ?Patients with stage 1-3A chronic kidney disease according to the KIDGO guidelines and 24-hour proteinuria > 0.5g ?Patients agreed to participate in this project.
Exclusion criteria
Exclusion criteria: ?Patients who have received kidney replacement therapy such as hemodialysis or are expected to enter maintenance dialysis within 3 months; ? Patients with history of antibiotic or probiotics use within 3 months; ? Patients with coronary heart disease, acute and chronic heart failure, acute infectious diseases, cerebral infarction, gastrointestinal bleeding, hepatitis, tumor and other diseases in recent 6 months;? Patients who are critically ill, and expected survival less than six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| abundance and diversity of gut flora;reduction in 24h proteinuria greater than 50%;reduction in serum creatinine more than 1/3 of baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| change in blood urea nitrogen;change in estimated glomerular filtration rate ;change in PCS;change in IS;change in IAA;change in 24h proteinuria;change in urine ACR;incidence of carvascular and cerebrovascular disease; | — |
Countries
China
Contacts
Public ContactAihua Zhang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed