Low grade intraepithelial neoplasia of the stomach
Conditions
Interventions
Treatment group:On the basis of symptomatic treatment with conventional Western medicine,oral Chinese herbal decoction (composed of Curcuma zedoary, Astragalus membranaceus, raw Coix seed, premedicate
control group:symptomatic treatment with conventional Western medicine
Sponsors
Fengxian People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Confirmed by gastroscopy and histopathology as chronic gastritis with low-level intraepithelial tumors, with or without atrophy and intestinal metaplasia; 2) Age range from 18 to 75 years old (including upper and lower limits), regardless of gender; 3) The patient understands and understands the study protocol and signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with a lesion range exceeding 2cm, including peptic ulcers, upper gastrointestinal bleeding, and low-level intraepithelial neoplasia, as well as those with high-level intraepithelial neoplasia or gastric cancer; 2) Individuals with a history of gastric surgery; 3) Individuals with severe liver and kidney dysfunction, i.e. alanine transferase (ALT) and aspartate transferase (AST), are greater than or equal to the upper limit of 3 normal values (3ULN); Alkaline phosphatase (ALP) = 2 ULN; Total bilirubin (TBIL) greater than 1.5 ULN;; Serum creatinine (CR) greater than 1.5ULN or creatinine clearance rate (CCR) less than 80 ml/min. If one of the above exists; 4) Long term use of non-steroidal anti-inflammatory drugs, hormones, proton pump inhibitors, H2 receptor blockers, and other treatments; 5) Digestive system diseases such as chronic pancreatitis and liver cirrhosis, or systemic diseases such as hyperthyroidism that affect gastrointestinal motility; 6) Patients with severe organic damage to the heart, lungs, brain, and blood system, patients with other organ tumors, and patients with mental illness; 7) Pregnant and lactating women; 8) Individuals with severe allergic constitution who are allergic to the drugs in this study; 9) Participated in other clinical trials in the past 2 months; 10) The researcher believes that there are any other circumstances that are not suitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall effective rate of gastric mucosal histopathology score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effective rate of integrating mucosal signs under gastroscopy;Clinical syndrome efficacy score effective rate; | — |
Countries
China
Contacts
Public ContactJiang Zhenzhen
Fengxian People's Hospital
Outcome results
None listed