Effect of subanesthetic and anesthetic doses of esesketamine on cardiac systolic and diastolic function in the elderly

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076124

Enrollment

Unknown

Registered

2023-09-25

Start date

2023-02-01

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The systolic and diastolic functions of the heart

Interventions

Subanesthetic dose group :Injection 0.25mg / kg esketamine

Anesthetic dose group:Injection 0.5mg / kg esketamine

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. = 65 years old 2.ASA ?-? 3.transthoracic echocardiography can be performed 4. The patient and their family understand and voluntarily sign the informed consent form 5. Planned to undergo elective tracheal intubation surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Ejection fraction (EF) <40% 2.Severe and poorly controlled hypertension 3.Hyperthyroidism with untreated or poor efficacy 4.Severe arrhythmia 5.Renal ischaemia 6.Aneurysmal vascular disease (including thoracic aorta, abdominal aorta, intracranial, and peripheral arteries) or arteriovenous malformations 7. History of cerebral hemorrhage 8. Allergy to esketamine and ketamine 9.There were acute angina pectoris, acute myocardial infarction, and previous cardiac interventions in the last 12 months 10.With acute pulmonary infected patients or liver and kidney insufficiency

Design outcomes

Primary

Measure	Time frame
Ejection fraction (EF);Ratio of maximum flow velocity in early diastolic phase to maximum flow velocity in late diastolic phase (E / A);	—

Secondary

Measure	Time frame
Left ventricular end-diastolic diameter (Dd);Left ventricular end-systolic diameter (Ds);Left ventricular outflow tract diameter;Aortic flow velocity integral (VTI);Maximum left atrial volume;Heart rate;Blood pressure;Early diastolic maximum velocity of mitral annulus (e '), late diastolic maximum velocity of mitral annulus (a');Left atrial volume index;Blood pressure heart rate product (RPP);	—

Countries

China

Contacts

Public ContactLei Hongyi

Zhujiang Hospital, Southern Medical University; Longgang District Central Hospital of Shenzhen

leihongyi2012@163.com+86 13143506862

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026