ACLF combined with infection
Conditions
Interventions
Treatment group:Give artificial liver PDF+DPMAES treatment (1-3 times), combined with traditional Chinese medicine decoction "Shengsheng Tang" enema and traditional Chinese medicine "Bugan Shengsheng
control group:Provide artificial liver PDF+DPMAES treatment (1-3 times), receive routine internal medicine comprehensive treatment, including bed rest, energy support, liver protection drugs, anti inf
Sponsors
Ankang Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Between the ages of 18 and 65, regardless of gender; (2) Have a history of chronic hepatitis B and no symptoms of decompensated cirrhosis; (3) Appearing digestive symptoms such as fatigue, anorexia, vomiting, or abdominal distension; (4) Serum TBil = 10 × ULN or daily increase = 17.1 µ Mol/L; (5) 30%<PTA = 50%; (6) There is evidence of infection.
Exclusion criteria
Exclusion criteria: (1) Co infection with human immunodeficiency virus (HIV), other hepatitis virus infections, or other liver damage; (2) Malignant tumors; (3) Acute attacks of cardiovascular and cerebrovascular diseases; (4) Renal failure; (5) Pregnant and lactating women; (6) Mental illness patients; (7) Severe active bleeding or disseminated intravascular coagulation; (8) Highly allergic to blood products or drugs used during the treatment process, such as plasma, heparin, and protamine; (9) Severe circulatory failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate on day 28 and day 90; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function (total bilirubin, albumin);Coagulation function (international standardized ratio, PT activity);Procalcitonin, PCT;C-reactive protein, CRP ;IL-6;Model for End-Stage Liver Disease, MELD ; | — |
Countries
China
Contacts
Public ContactXianwen Cheng
Ankang Traditional Chinese Medicine Hospital Affiliated to Shaanxi University of Traditional
Outcome results
None listed