osteoporosis
Conditions
Interventions
Probiotics group:Lactobacillus fermentans
Sponsors
Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu Province
Eligibility
Sex/Gender
Female
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? By bone mineral density CT and serum bone-related biochemical indicators (such as bone alkaline phosphatase, tartrate-resistant acid phosphatase, parathyroid hormone, etc.) examination, clinical diagnosis of osteopenia or osteoporosis patients; ? Postmenopausal women over 50 years old; ? The patient has no severe disease (such as a malignant tumor) or history of upper gastrointestinal tract (such as bradycardia); ? No secondary or idiopathic osteoporosis, no major illness or long-term medication history, and do not take any hormones, osteoporosis, or other drugs that will interfere with bone health during the study; ? Promise to cooperate with the research throughout the experiment, and be willing to provide written informed consent and basic information questionnaires ? For infectious diseases that do not need to be treated with antibiotics, antibiotics have not been used for nearly 1 month (except for local drugs), and probiotic drugs or foods containing probiotics have not been used for nearly 1 month (such as probiotic yogurt, pickles, etc.).
Exclusion criteria
Exclusion criteria: ? A history of gastrointestinal surgery (except appendectomy); ? Has secondary and idiopathic osteoporosis; ? Have a history of any serious disease (serious cardiovascular, endocrine, liver and kidney dysfunction, etc.); ? Patients were also excluded if they had taken antibiotics or probiotic products in the month prior to study inclusion; ? Participants in other clinical trials; ? Unwilling or unable to provide written informed consent to participate in the study after the researcher has notified the researcher of the purpose, process, and possible risks; ? Does not meet the requirements of the study or the researchers think that they should not participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density;Serum 25 hydroxyvitamin D;Intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum biochemistry;Intestinal metabolites; | — |
Countries
Chian
Contacts
Public ContactQixiao Zhai
School of Food Science, Jiangnan University
Outcome results
None listed