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Study on the Characteristics of Perivascular Adipose Tissue in Patients with Coronary Atherosclerotic Heart Disease by Single Nuclei RNA Sequencing

Study on the Characteristics of Perivascular Adipose Tissue in Patients with Coronary Atherosclerotic Heart Disease by Single Nuclei RNA Sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300076110
Enrollment
Unknown
Registered
2023-09-25
Start date
2023-09-30
Completion date
Unknown
Last updated
2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Interventions

Coronary artery disease group:no intervention.
Non coronary artery disease group:no intervention.

Sponsors

Xi Yuan Hospital of China Academy of Chinese Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Coronary artery disease: (1) Comply with the "2021 ACC/AHA/SCAI Coronary Artery Revascularization Guidelines" jointly developed by the American Heart Association (ACC), American Heart Association (AHA), and Cardiovascular Angiography and Interventional Association (SCAI) for the management of bypass surgery; (2) Gender unlimited, adult patients aged 30-70 (including patients aged 30 and 70); (3) Informed consent and sign an informed consent form. 2. Non coronary atherosclerotic heart disease (valvular heart disease): (1) The cardiac surgical indications for valve repair and replacement surgery in accordance with the 2021 ESC/EACTS Guidelines for the Management of Valvular Heart Disease developed by the European Society of Cardiology (ESC) and the European Association of Cardiothoracic Surgeons (EACTS); (2) Gender unlimited, adult patients aged 30-70 (including patients aged 30 and 70); (3) Informed consent and sign an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Those with a heart function of Class IV; (2) Patients with concomitant rheumatic heart disease, active endocarditis, pulmonary hypertension, and ventricular septal rupture; (3) Acute phase of cerebral infarction; (4) Complication with severe primary diseases such as liver, kidney, and hematopoietic system; (5) There have been acute infections in the past 2 weeks; (6) Have a history of trauma or surgery within the past 2 months; (7) Those who have merged with other more serious diseases and must be treated (such as hematological diseases, tumors, etc.); (8) Uncontrolled hypertension (resting blood pressure>160/95mmHg within a week); (9) Diabetes does not reach the general control standard, or serious diabetes complications occur; (10) Informed consent notification related to mental, neurological, or intellectual disabilities that cannot cooperate with research; (11) Pregnant or lactating women; (12)During the surgery, the sample size did not meet the testing requirements.

Design outcomes

Primary

MeasureTime frame
Characteristics of Perivascular Adipose Tissue;

Countries

China

Contacts

Public ContactQu Hua

Xi Yuan Hospital of China Academy of Chinese Medical Sciences

hua_qu@yeah.net+86 188 1090 1378

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026