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rTMS regulates MPFC-amygdala circuit to improve fear extinction and neuroimaging mechanism in chronic insomnia disorder

rTMS regulates MPFC-amygdala circuit to improve fear extinction and neuroimaging mechanism in chronic insomnia disorder

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076097
Enrollment
Unknown
Registered
2023-09-25
Start date
2023-10-01
Completion date
Unknown
Last updated
2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic insomnia disorder

Interventions

Sponsors

Zhenjiang Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: a) Meet the ICSD-3 diagnostic criteria for chronic insomnia disorders; b) Aged 18-60 years; c) junior high school or above; d) Right-handed; e)PSQI=11 points; f) No insomnia medication taken in the last 4 weeks or no change in insomnia medication taken. No history of long-term use of anti-anxiety and depression drugs in the past six months; rTMS, transcranial direct current, electroshock and other physical therapy were not performed in the past six months. No drinking, smoking, coffee, strong tea and other habits, no history of staying up late within two weeks, shift.

Exclusion criteria

Exclusion criteria: a) A family history of mental illness or other mental illness; b) A history of alcohol, drug or psychoactive substance abuse; c) Insomnia caused by other sleep disorders, such as sleep apnea syndrome, restless leg syndrome, narcolepsy, periodic leg movement, etc.; d) suffering from serious medical system diseases including cardiovascular system, urinary system, respiratory system, digestive system and other serious physical diseases; e) Pregnant or lactating women; f) A history of neurological disease, including a history of craniocerebral trauma, space-occupying diseases, encephalitis and other organic diseases; g) Previous treatment of rTMS is not effective.

Design outcomes

Primary

MeasureTime frame
Skin conductance reaction;

Secondary

MeasureTime frame
Pittsburgh Sleep Quality;cognitive;

Countries

China

Contacts

Public ContactSun Jingjing

Zhenjiang Mental Health Center

599308249@qq.com+86 176 9603 1977

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026