Dry eye
Conditions
Interventions
Dry eye Group:NA
Sponsors
Xiamen eye center of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age = 18 years, any gender. Clear understanding and voluntary participation in the study, with written informed consent signed by the individual, willing to follow all the experimental assessments as instructed. A) The inclusion criteria for the non-dry eye population (control group) are as follows: Does not meet (fails to meet) the diagnostic criteria for dry eye and has a healthy ocular surface without other diseases. B) Inclusion criteria for dry eye patients: According to the "Chinese Expert Consensus on Dry Eye: Examination and Diagnosis (2020)", patients complain of subjective symptoms such as eye dryness, foreign body sensation, burning sensation, fatigue, discomfort, eye redness, fluctuating vision, with a Chinese Dry Eye Questionnaire score = 7 points or Ocular Surface Disease Index (OSDI) score = 13 points; at the same time, FBUT = 5s or NIBUT 5s and = 10s or NIBUT is between 10-12s, Schirmer I test (without anesthesia) is > 5 mm/5 min and = 10 mm/5 min, then corneal fluorescein staining should be performed, and positive staining (= 5 dots) can diagnose dry eye. Participants who use artificial tears should stop using them for at least 12 hours prior to the examination.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Any of the following criteria will result in the participant being ineligible for inclusion in this study: Floppy eyelid syndrome. Severe dry eye patients, especially those with severe aqueous deficiency. Severe blepharitis or severe meibomian gland dysfunction. History of lacrimal duct diseases such as lacrimal duct obstruction, dacryocystitis, or lacrimal plug surgery. History of ocular surgery within the past month. History of ocular or periocular malignant tumors. Dry eye caused by sequelae of scars (such as radiation, alkali burns, Stevens-Johnson syndrome, cicatricial pemphigoid) or destruction of conjunctival goblet cells (such as vitamin A deficiency). Acute phase of ocular allergy. Ocular or systemic infection (bacterial, viral, or fungal), including fever, herpetic keratitis, or undergoing antibiotic treatment. History of any immunodeficiency, HIV infection, hepatitis B, hepatitis C, acute active hepatitis A (positive anti-HAV IgM), organ or bone marrow transplantation. Any significant chronic diseases that the investigator deems may interfere with the study parameters.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SMTube; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Chinese Dry Eye Questionnaire;ocular?surface?disease?index, OSDI; tear meniscus height;tear film break up time;redness;Fluorescein Staining;Schirmer I test;Eyelid mergin assessment; | — |
Countries
China
Contacts
Public ContactLiu Zuguo
Eye Institute of Xiamen University
Outcome results
None listed