Severe high triglyceride fatty liver disease
Conditions
Interventions
Observation group :Treat once with blood purification DFPP mode, supplemented by oral administration of traditional Chinese medicine "Bugan Lizhi Tang" for 24 weeks
control group:Using blood purification DFPP mode for treatment once, assisted by oral administration of bezafibrate for 24 weeks
Sponsors
Ankang Traditional Chinese Medicine Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) No history of alcohol consumption or alcohol consumption equivalent to less than 140g/week for males and less than 70g/week for females; (2) Excluding specific diseases that can lead to fatty liver, such as viral hepatitis, drug-induced liver disease, total parenteral nutrition, hepatolenticular degeneration, autoimmune liver disease, etc; (3) The manifestations of liver imaging meet the diagnostic criteria for diffuse fatty liver and there are no other reasons to explain; (4)Patients with metabolic syndrome components experience continuous increases in liver function ALT and/or AST, GGT, but not exceeding the normal upper limit by 5 times. (5) Triglycerides greater than 11.3 mmol/L.
Exclusion criteria
Exclusion criteria: 1) Alcoholic fatty liver disease; (2) Viral hepatitis (A, B, C, D, E); (3) Liver cirrhosis and primary liver cancer; (4) Pregnant and lactating women; Mental disorders, renal dysfunction, complications of diabetes, acute coronary syndrome and serious organic diseases; (5) Drug induced liver injury, autoimmune liver disease, hepatolenticular degeneration;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| triglyceride;APO-A1;APO-B;LSM; | — |
Secondary
| Measure | Time frame |
|---|---|
| HCBP6 protein;uric acid;ALT;AST;HDL-C;URBC;Bun/SCr/eGFR;ALB;Traditional Chinese Medicine Syndrome Points;LDL-C; | — |
Countries
China
Contacts
Public ContactXianwen Cheng
Ankang Traditional Chinese Medicine Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine
Outcome results
None listed