High triglyceride induced moderate/severe acute pancreatitis
Conditions
Interventions
Intervention group:All patients received routine internal medicine comprehensive treatment, mainly including acid suppression, enzyme inhibition, and fluid replacement. The observation group was assis
control group:Receive routine internal medicine comprehensive treatment, mainly including acid suppression, enzyme inhibition, and fluid replacement. Control group assisted with CPFA treatment: After
Sponsors
Ankang Traditional Chinese Medicine Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Acute, sudden, persistent, and severe upper abdominal pain that can radiate to the back; (2) The activity of serum amylase and/or lipase is at least three times higher than the normal upper limit value; (3) CT/MRI shows typical imaging changes of AP (pancreatic edema or peripancreatic effusion); If 2 of the above 3 criteria are met, it can be diagnosed as AP. (4) Accompanied with transient organ failure or local/systemic complications. (5) Triglycerides = 11.3 mmol/L.
Exclusion criteria
Exclusion criteria: The patient had coronary atherosclerotic heart disease and the cardiac function score was ? - ?; Malignant tumors; Acute attack period of cardiovascular and cerebrovascular diseases; Chronic renal failure; Pregnant and lactating women, mental illness patients, aged over 79 years old. And there are the following: severe active bleeding or disseminated intravascular coagulation; Highly allergic to blood products or drugs used during the treatment process, such as heparin and protamine; Patients with circulatory dysfunction; Patients with unstable stage of myocardial infarction; Late pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Triglycerides, cholesterol, high-density lipoprotein, low-density lipoprotein;CRP; survival rate;electrolyte; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dual source CT severity index score;cytokine:IL-6;TNF-a;IL-17;IL-10;IL-35;liver function;renal function;Endotoxins, D-lactate, diamine oxidase;APACHE II score, MODS score;Blood amylase, blood lipase;Procalcitonin;Blood routine; | — |
Countries
China
Contacts
Public ContactXianwen Cheng
Ankang Traditional Chinese Medicine Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine
Outcome results
None listed