Postoperative nausea and vomiting
Conditions
Interventions
C group:One hour before operation, the patient took oral placebo
A group:Oral olanzapine 10mg was given to patients 1 hour before operation
Sponsors
Linyi People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Obtain informed consent. 2) Scheduled for elective breast cancer surgery under general anesthesia. 3) American Association of Anesthesiologists (ASA) rating I~II. 4) Age >18 years old.
Exclusion criteria
Exclusion criteria: 1) Severe pre-operative cardiopulmonary disease or neurological disorder; 2) Have a history of mental illness or long-term use of psychotropic drugs, chronic analgesic history; 3)lactating, had a preoperative corrected QT interval greater than 450ms, or had a history of torsades de pointes. 4) use glucocorticoids, opioids or antiemetic drugs 24 hours before operation. 5) Allergy to experimental drugs or other contraindications; 6) Participated in additional drug clinical studies in the past 30 days;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting;Nausea?Vomiting score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emergency agitation;Standard self-rated comfort;Anesthesia satisfaction;Intraoperative Hemodynamics;The anesthetic dosage;The total hospitalization days;PACU stay time;Pain scores;Extubation time;The time eye opening; | — |
Countries
China
Contacts
Public ContactZiyao Jiao
Linyi People's Hospital
Outcome results
None listed