Cardiovascular disease
Conditions
Interventions
control group:Replacing Cooking Oil with Olive Oil
Intervention group A:Sunflower Oil (high oleic acid + Vitamin A)
Intervention group B:Sunflower(High linoleic acid + Vitamin A)
Intervention group C:Sunflower(High linoleic acid)
Sponsors
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The age of the study subjects was 45-75 years old (2) Length of residence in Wuhan City, Hubei Province = 5 years (3) Cooking oil energy supply ratio =20% (4) In general, the frequency of home cooking (Chinese food and dinner) was =5 days/week (5) ASCVD risk assessment 10-year cardiovascular risk is moderate or high risk (6) No allergic or hypersensitivity reactions to one or more components of vegetable oils involved in this study (7) Able to read, write and communicate verbally in Chinese, and able to use smart phones and other related communication devices independently or with the help of others (8) Be aware of the intervention test and voluntarily participate in the study
Exclusion criteria
Exclusion criteria: (1) Combined coronary heart disease, hepatic or renal insufficiency, malignancy, asthma, active hyperthyroidism, untreated or unstable hypothyroidism, multiple sclerosis, gastrointestinal disease, pancreatic disease, autoimmune system disease; or history of neurological or psychiatric disorders such as cognitive dysfunction, or currently taking medications for neurological or psychiatric disorders, such as antidepressants (2) Participation in other clinical trials, diet or exercise intervention programs within the last 3 months (3) Major surgery or cardiovascular event, irritable bowel syndrome (IBS), acute or chronic infection within the last 6 months (4) Taking lipid-lowering drugs or other drugs or foods that affect the lipid profile, or taking dietary supplements within the last 3 months (5) Large fluctuations in weight (±5%) within the last 1 month (6) Alcohol or drug abuse within the last 1 month (7) Existence of special dietary habits, such as ketogenic diet, etc. (8) Inability to tolerate physical examinations or imaging tests involved in the study, such as functional MRI, etc. (9) Have definite plans to go abroad or travel within the next 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood lipid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular risk score;Body fat rate;Endothelial vascular function;Levels of inflammatory factor secretion;Glycated hemoglobin;Fatty acid profile;Serum vitamins;Intestinal flora;Metabolites of intestinal flora;Glycosylation end products;Cholesterol efflux capacity;Muscle mass;De-fatted weight;Serum insulin;Fasting blood sugar;Serum minerals;Urine Routine; | — |
Countries
China
Contacts
Public ContactShuang Rong
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University
Outcome results
None listed