Parkinson's
Conditions
Interventions
Intravenous anesthesia group:Total intravenous anesthesia maintenance by propofol
nhalation anesthesia maintenance:nesthesia maintenance by sevoflurane
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Select patients aged 18-65 with primary Parkinson's disease; 2. It is effective for levodopa drugs and the experimental response rate of levodopa drugs is>30%; 3. No cognitive impairment, no serious depression, anxiety or other mental illness complications; 4. The head MRI examination is basically normal, and there is no serious organic lesion.
Exclusion criteria
Exclusion criteria: 1. Secondary Parkinson's disease or Parkinson's syndrome; 2. Merge other important organ lesions such as heart, liver, and kidney in the system; 3. Patients with concomitant mental illness or cognitive impairment, 4. Those who are unable to complete the scale or voluntarily withdraw from this study midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parkinson's scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tau;p-Tau;Aß42;s100ß;IL-17, IL-1ß, TNF-a;MDH, SOD; | — |
Countries
China
Contacts
Public ContactFang Kang
The First Affiliated Hospital of University of Science and Technology
Outcome results
None listed