Acute circulatory failure
Conditions
Interventions
Gold Standard:Fluid responsiveness was defined as an increase > 10% in stroke volume (measured by transthoracic echocardiography) after passive leg raising test
Index test:Changes in pulse pressure variation, velocity-time integral and peak velocity variability of left ventricular outflow tract after tidal volume challenge
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Acute circulatory failure in mechanically ventilated critically ill patients transferred to the ICU: systolic blood pressure less than 90 mmHg, systolic blood pressure of hypertensive patients decreased by more than 40mmHg (or need norepinephrine for maintenance); Urine output is less than 0.5 ml/kg per hour and lasts for more than 1 hour; Tachycardia, heart rate 100 beats /min; Skin mottling; Lactic acid greater than 2mmol/L.
Exclusion criteria
Exclusion criteria: Under 18 years of age; dying patient; primary cardiomyopathy; pulmonary edema; intra-abdominal hypertension; increased intracranial pressure; active bleeding; atrial fibrillation; severe arrhythmia; heart failure and myocardial infarction; poor transthoracic ultrasound imaging; lower limb fracture; lower limb disability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke volume;Maximal velocity-time integral;Minimal velocity-time integral;Maximal peak velocity;Minimal peak velocity;Receiver operating characteristic ( ROC) curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;Central venous pressure;Pulse pressure variation; | — |
Countries
China
Contacts
Public ContactJin Xie
The First Affiliated Hospital of Soochow University
Outcome results
None listed