Bacterial meningitis in children
Conditions
Interventions
Model treatment group:40mg/kg/dose,q8h,with 3h infusion
Conventional treatment group:40mg/kg/dose,q8h,with 0.5h infusion
Sponsors
Baoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
0.2 Years to 15 Years
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria are eligible for admission to this clinical trial: 1.1 Children between 3 months and 15 years old; 1.2 The etiology or clinical diagnosis is bacterial meningitis (Reference: Neurology Group, Pediatrics Society of the Chinese Medical Association). Expert consensus on diagnosis and treatment of community-acquired bacterial meningitis in children [J]. Chinese Journal of Pediatrics,2019,57 (8): 584-591. (in Chinese) DOI: 10.3760/cma.j.issn.0578-1310.2019.08.003). 1.3 Anti-infective therapy with meropenem; 1.4 The clinical course of meropenem is expected to be longer than 48 hours; 1.5 Renal function was normal, and serum creatinine, blood urea nitrogen and creatinine clearance were all within the normal range.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following exclusion criteria shall not be admitted to this clinical trial: 2.1 Allergic to meropenem; 2.2 Receiving other experimental drugs; 2.3 The expected survival may be shorter than the treatment cycle; 2.4 Children not considered suitable for inclusion in the study by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood drug concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| white blood cells;blood neutrophils;C-reactive protein; | — |
Countries
China
Contacts
Public ContactJing Bi/Adong Shen
Baoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University
Outcome results
None listed