Cryptococcal meningitis, cryptococcal disease
Conditions
Interventions
Gold Standard:Cryptococcal pneumonneumococcal infection: diagnosis is confirmed primarily by histopathological examination and aetiological smear and culture of intralesional pus aspiration specimens.
Index test:The main index of the detection in this clinical trial was cryptococcus capsular polysaccharide, which was expected to have a sensitivity of 98% and a specificity of 99%. CSF detection sens
If the concentration of capsular polysaccharides = 2 ng/mL, it is considered positive, indicating a higher risk of infection with cryptococcus.
tases.
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 100 Years
Inclusion criteria
Inclusion criteria: Serum sample inclusion criteria 1) The background information of the sample source case should meet the requirements (including immunocompetent people and immunocompromised people): a) or be a case of clinically diagnosed cryptococcal infection. b) or suspected cases of cryptococcal infection (including patients with suspected cryptococcal infection in various parts of the lungs, central nervous system, or skin). c) or some rheumatoid factor positive cases, systemic lupus erythematosus cases, and cases of Trichosporidium infection. 2) Sample content= 0.4mL. Criteria for selection of cerebrospinal fluid samples 1) Background information requirements for sample source cases (including immunocompetent people and immunocompromised people): a) or a case of clinically diagnosed cryptococcal meningitis. b) or suspected case of cryptococcal meningitis. c) or cases of bacterial meningitis (gram-positive and gram-negative should be included), tuberculous meningitis, viral meningitis, and autoimmune encephalitis. 2) Sample content= 0.4mL.
Exclusion criteria
Exclusion criteria: Exclusion criteria 1) Serum samples of severe hemolysis and lipidemia; 2) Lipid-cloudy cerebrospinal fluid sample; 3) The investigator believes that the sample does not meet the requirements of the testing requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Capsular polysaccharide concentration;Accuracy ;Sensitivity ;Specificity ;Positive predicative value; | — |
Countries
China
Contacts
Public ContactLIXI
Zhejiang Provincial People's Hospital
Outcome results
None listed