tonsillar adenoidectomy
Conditions
Interventions
micuronium chloride group: micuronium chloride induction
Cis-atracurium :Cis-atracurium induction
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1) Sign informed consent; 2) Preschool children aged 3-6 years; 3) ASA grade I; 4) Subjects with tonsil adenoidectomy under quasi-general anesthesia; 5) Meet the weight standard:Weigh more than 13kg and less than 26kg;
Exclusion criteria
Exclusion criteria: 1) Difficult airway and severe respiratory diseases, acute respiratory infections, uncontrolled asthma and unexplained dyspnea; 2) Paediatric population requiring special care or supervision by courts/social welfare institutions; 3) Subjects with mental system diseases and cognitive dysfunction and a history of epilepsy; 4) Subjects with cardiovascular diseases (such as congenital heart disease, bradycardia requiring treatment, hypotension requiring treatment, etc.); 5) Subjects with abnormal liver function, alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) exceeding 1.5 times the upper limit of normal; Subjects whose total bilirubin exceeds the upper limit of normal; Subjects with abnormal renal function and blood creatinine exceeding the upper limit of normal; 6) Abnormal plasma cholinesterase activity or pseudocholinesterase deficiency; 7) Participated in other clinical trials (received experimental drug or placebo) within 3 months before surgery; 8) Long-term use of drugs that affect muscle nerve conduction and allergic to narcotic drugs; 9) Other conditions deemed unsuitable for participation in this clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle relaxation aging index;vital signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction;General information included age, sex, body mass index, and duration of surgery; | — |
Countries
China
Contacts
Public ContactShangguan Wangning
Wenzhou Medical University Affiliated Stomatological Hospital
Outcome results
None listed