Colorectal Cancer
Conditions
Interventions
Gold Standard:Colonoscopy, Pathological biopsy
Index test:Feces, SDC2/NDRG4 Gene Methylation Detection Kit
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
38 Years to 93 Years
Inclusion criteria
Inclusion criteria: 1: Prospective samples must simultaneously meet the following conditions: ? subjects = 45 years old; ? Those who meet any of the following conditions: (i) have changes in bowel habits and symptoms that meet either of the following two conditions: (1) changes in stool characteristics (such as diarrhea, constipation, mucus stools, etc.); (2) Increased frequency of bowel movements (more than three times a day); (3) History of chronic Appendicitis or Appendicitis resection; (4) History of chronic Cholecystitis or Cholecystitis resection; (5) Unexplained anemia or weight loss; (6) Long term mental depression; (ii) Samples requiring colonoscopy due to suspected other digestive system tumors (such as esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, Cholangiocarcinoma, etc.); (iii) Samples requiring colonoscopy due to suspected other benign diseases of digestive system (such as gastritis, enteritis, Appendicitis, colitis, peptic ulcer, etc.); ? The subjects voluntarily participated in this study and signed a written informed consent form. 2: Retrospective samples: The inclusion of retrospective samples must simultaneously meet the following conditions: ? subjects = 45 years old; ? The results of the colonoscopy examination of the subjects showed positive results for colorectal cancer.
Exclusion criteria
Exclusion criteria: ? Those unable to complete any one of the fecal Genetic testing or colonoscopy ? Subjects have received chemotherapy and other anti-tumor treatment before participating in the study ? Subjects are still participating in other clinical trials within three months before participating in the study ? Subjects samples that the researchers think are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity of the Kit in the diagnosis of colorectal cancer;Specificity of the Kit in the diagnosis of colorectal cancer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity of the Kit in the diagnosis of colorectal cancer tumors in different stages;The specificity of the kit for various types of adenomas; | — |
Countries
China
Contacts
Public ContactWeidong Liu
Xiangya Hospital of Central South University
Outcome results
None listed