patients with general anesthesia
Conditions
Interventions
Remimazolam dose 0.25 mg/kg:Anesthesia was induced with remimazolam 0.25mg/kg, and the 50% effective dose of sufentanil was determined.
Remimazolam dose 0.35 mg/kg:Anesthesia was induced with remimazolam 0.25mg/kg, and the 50% effective dose of sufentanil was determined.
Sponsors
Department of Anesthesiology, Nanchong City Hospital, Second Clinical Medical College, North Sichuan Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Patients undergoing elective general anesthesia surgery, regardless of gender, aged 18-65 years; ? BMI 19-28kg/m2; ?ASA ?-?; All participants agreed to participate in the study and signed
Exclusion criteria
Exclusion criteria: (1) Acute heart failure, unstable angina, or myocardial infarction within 6 months. ? Enter the room to measure the baseline values: systolic blood pressure > 160mmHg or diastolic blood pressure > 100mmHg, heart rate 100bpm. Acute respiratory infection, acute exacerbation of COPD, poorly controlled asthma ? End-stage renal failure and hepatic decompensation ? Mental disorders including: schizophrenia, depression, cognitive dysfunction, etc. ?Allergy to the study drug (vii) History of benzodiazepine medication in the last three months. ? Pregnant and lactating women. ? Patients with anticipated difficult airways.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| median effective dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs during intubation;Time to complete endotracheal intubation;Number of adverse reactions; | — |
Countries
China
Contacts
Public ContactLi Linji
Department of Anesthesiology, Nanchong City Hospital, Second Clinical Medical College, North Sichuan Medical College
Outcome results
None listed