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Effect analysis of Corneal Collagen Cross-Linking with Improved Methodology (accelerated epithelium-on corneal collagen cross-linking with corneal epithelial point scraping and surface scraping and accelerated epithelium-off corneal collagen cross-linking with reduced energy ) for Progressive Keratoconus with a Thin Cornea

Effect analysis of Corneal Collagen Cross-Linking with Improved Methodology (accelerated epithelium-on corneal collagen cross-linking with corneal epithelial point scraping and surface scraping and accelerated epithelium-off corneal collagen cross-linking with reduced energy ) for Progressive Keratoconus with a Thin Cornea

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300075921
Enrollment
Unknown
Registered
2023-09-19
Start date
2023-09-19
Completion date
Unknown
Last updated
2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

keratoconus

Interventions

Group of improved ACXL:NA
Group of ACXL:NA

Sponsors

Qingdao Eye Hospital affiliated to Shandong First Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed with Keratoconus, and tCorneal stroma thickness below 400 µm and the full thickness of the cornea is above 330 µm; 2. Adult patients with Keratoconus whose maximum corneal curvature (Kmax) increased by more than 1.0D in the past 1 year; 3.9~19 years old adolescent patients with Keratoconus; 4. Those with no obvious scars on the corneal stroma.

Exclusion criteria

Exclusion criteria: Patients with a corneal thickness (TCT) less than 330µm, corneal opacity, ocular surgery, active infections, ocular surface disease, autoimmune disease, and pregnancy or lactation were excluded.

Design outcomes

Primary

MeasureTime frame
corneal curvature;thinnest corneal thickness;subjective refraction;best correction of visual acuity;Endothelial Cell Density;—

Countries

China

Contacts

Public ContactChenpei Zhao

Qingdao Eye Hospital affiliated to Shandong First Medical University

zhaochenpeipei@163.com+86 185 6253 4244

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026