Osteoporotic vertebral fracture
Conditions
Interventions
Osteoprosis vertebral compression fracture:N/A
Kummell disease:N/A
Non-osteoporosis:N/A
Sponsors
the Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
63 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for osteoporotic vertebral compression fractures were as following: (1) age = 50 years with symptomatic low back pain without any neurological symptoms or signs; (2) Computer Tomography(CT)or Magnetic Resonance Imaging(MRI)showed fresh vertebral compression fractures (evidenced by vertebral compression or collapse); (3) bone mineral density(BMD T-score = -2.5. The inclusion criteria for Kummell's disease were as following: (1) age = 50 years with symptomatic low back pain, without any neurological symptoms or signs; (2) CT or MRI displayed vertebral collapse with bone necrosis as well as positive signs of intravertebral cleft and double-line ; (3) BMD T-score = -2.5. The inclusion criteria for the control group were: (1) age = 50 years; (2) BMD T-score > -2.5.
Exclusion criteria
Exclusion criteria: (1) patients with malignant tumors, severe coagulation disorders, or hematological diseases; (2) patients with bacterial or viral infections such as pneumonia, influenza,human immunodeficiency virus( HIV), hepatitis B, etc., stroke, or acute myocardial infarction; (3) Patients with hepatic and renal insufficiency; (4) patients who have been treated with glucocorticoids or immunosuppressive agents for a long time, or those with immune dysfunction; (5) secondary vertebral compression fractures caused by presence of other diseases such as vertebral tumors or tuberculosis; (6) patients suffering with endocrine diseases (such as Cushing's syndrome, hyperthyroidism, hyperparathyroidism, Paget's disease); (7) patients who cannot tolerate surgery or have refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-1;IL-6;TNF-a;TGF-ß; | — |
Countries
China
Contacts
Public ContactSong Wang
the Affiliated Hospital of Southwest Medical University
Outcome results
None listed