Osteomyelitis
Conditions
Interventions
Internal fixation group:None
Sponsors
First affiliated hospital, Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.18-65 Y, male or female 2.Definitive diagnosis with chronic osteomyelitis of lower limb 3.Cierny-Mader Type IV osteomyelitis 4.Acceptance the staged therapeutic schedule(first stage: debridement and implanted with bone cement, second stage:repair the bone defects)
Exclusion criteria
Exclusion criteria: 1.Expected inability to achieve skin and soft tissue coverage after debridement 2.Acute onset of osteomyelitis; 3.Osteomyelitis combined with adjacent joint infection; 4.Multiple site bone infections; 5.Combined with other serious injuries (craniocerebral injury, lung blast injury, abdominal organ injury, etc.); 6.Moderate to severe anemia, hypoproteinemia, and unstable vital signs; 7.Accompanied with serious physical and mental illnesses, including uncontrolled metabolic disorders, immunodeficiency, mental illness, suspected malignant tumors, or with history of malignant tumors; 8.Have received corticosteroids, immunosuppressants, and chemotherapy drugs within 6 months prior to enrollment (using them for more than 2 weeks); 9.Expected inability to achieve complete debridement or uncontrollable infection before surgery; 10.The pathogenic bacteria are Pseudomonas aeruginosa; 11.The pathogenic bacteria are Fungi or tuberculosis bacteria; 12.Participating in other clinical trials; 13.Researchers thought the situations that are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection control rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infection control rate;Complication rate; | — |
Countries
China
Contacts
Public Contactluofei
First affiliated hospital, Third Military Medical University(Army Medical University),PLA
Outcome results
None listed