urological laparoscopic surgery
Conditions
Interventions
Group K1:continuous intravenous infusion of esketamine at a rate of 0.125 mg/kg/h
Group K2:continuous intravenous infusion of esketamine at a rate of 0.25 mg/kg/h
Group C:continuous intravenous infusion of saline at the same rate
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.patients undergoing elective urological laparoscopic surgery; 2. Aged 18 to 65 years; 3. ASA physical health status I or II
Exclusion criteria
Exclusion criteria: Diagnosed mental illness; history of drug or alcohol abuse; BMI30 kg/m2; severe hepatic or renal insufficiency; known hypersensitivity to esketamine; contraindications to the use of esketamine injection for any of the following conditions: serious risk of elevated blood pressure or intracranial pressure, high intraocular pressure (glaucoma) or penetrating ocular trauma, poorly controlled or untreated hypertension (SBP/DBP >180/110 mmHg at rest), untreated or inadequately treated hyperthyroidism (hyperthyroidism); pregnancy or breastfeeding; communication difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bispectral index; | — |
Secondary
| Measure | Time frame |
|---|---|
| spectral edge frequency 95;intraoperative mean arterial pressure;intraoperative heart rate ;intraoperative dosage of metaraminol;Intraoperative adverse cardiovascular events;time of extubation;Ricker Sedation-Agitation Scores;Resting and active NRS pain scores;Aldrete scores;Re-sedation;remedial analgesia;emergence agitation;PACU length of stay;postoperative quality of recovery;postoperative sleep quality;moderate-to-severe pain;adverse reaction; | — |
Countries
China
Contacts
Public ContactWang Yanping
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed