sepsis
Conditions
Interventions
Healthy Adult Group:This study was a case-control study with no intervention.
Type 2 diabetes group:This study was a case-control study with no intervention.
Sepsis in combination with type 2 diabetes:This study was a case-control study with no intervention.
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Part one Functional and morphological changes in red blood cells 123 patients with type 2 diabetes admitted to the Second Hospital of Dalian Medical University from September 2023 to September 2024 were selected (inclusion criteria met WHO 1999 diagnostic criteria for diabetes and glycosylated haemoglobin fluctuations of no more than 1% in the 3 months prior to admission); 123 patients with sepsis in combination with type 2 diabetes (inclusion criteria sepsis sepsis 3.0 diagnostic criteria. meeting WHO 1999 diagnostic criteria for diabetes mellitus, with glycosylated haemoglobin fluctuations of no more than 1% in the 3 months prior to admission) and 123 healthy physicals selected as controls during the same period. Part two Erythrocyte subpopulation identification and functional analysis 3 patients with type 2 diabetes admitted to the Second Hospital of Dalian Medical University from September 2023 to September 2024 were selected (inclusion criteria met WHO 1999 diagnostic criteria for diabetes and glycosylated haemoglobin fluctuations of no more than 1% in the 3 months prior to admission); 3 patients with sepsis in combination with type 2 diabetes (inclusion criteria sepsis sepsis 3.0 diagnostic criteria. meeting WHO 1999 diagnostic criteria for diabetes mellitus, with glycosylated haemoglobin fluctuations of no more than 1% in the 3 months prior to admission) and 3 healthy physicals selected as controls during the same period.
Exclusion criteria
Exclusion criteria: (i) age <18 years; (ii) malignancy; (iii) acquired immunodeficiency syndrome; (iv) autoimmune system disease; (v) receiving immunosuppressive treatment; (vi) those who withdrew from the study midway. (vii) Exclusion of diseases and drug users that may affect the morphology, function, physicochemical properties and immune function of red blood cells;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Haemoglobin;2,3-DPG concentration;Na+-K+-ATPase concentration;RDW-CV;Erythrocyte morphology;Erythrocyte oxygen affinity;Serum 8-iso-pgf2a ;Sequential Inertial Organ Failure Score (SOFA score);Sequencing the single-cell transcriptome of a subpopulation of peripheral blood immune erythrocytes;Epigenomics of immune red blood cell subpopulations in peripheral blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2;PaCO2;SaO2; | — |
Countries
China
Contacts
Public ContactYang Chuwei
The Second Hospital of Dalian Medical University
Outcome results
None listed