Major Depressive Disorder
Conditions
Interventions
Sponsors
Institute of Psychology, Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-35 years old; 2. Patients with treatment-resistant depression (TRD): Depressed individuals with a Hamilton Depression Scale (HAMD) score reduction of <20% after a full course of treatment with 2 or more antidepressants, TMS-naive; 3. Have fluent reading and writing skills to ensure that they can understand the instructions; 4. Sign the informed consent; 5. Suitable for MRI examination: (1) No metal or electronic implants in the body (such as metal cochlear implants or pacemakers); (2) No prosthesis (such as dentures, metal braces, etc.); (3) No hair dying or tattooing; (4) No claustrophobia; (5) No severe spondylosis; (6) No traumatic brain injury.
Exclusion criteria
Exclusion criteria: 1. Suffering from diseases that may affect the ability to complete the experiment ; 2. The brain has been injured, or has suffered a severe blow to the head and has been unconscious for more than 10 minutes; 3. Severe impairment of vision/hearing or hand movement, which makes it impossible to complete the experiment or understand the requirements of the experiment; 4. Pregnant/lactating women; 5. Contraindications for magnetic resonance examination (claustrophobia or metal or electronic implants in the body); 6. Substance abuse or alcohol abuse; 7. Schizoaffective disorder, schizophrenia, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, memory impairment or other cognitive disorders; 8. Personality disorders, mental retardation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depressive symptoms;depressive state ;Resting-state fMRI;diffusion tensor imaging;3D-T1 structural imaging;state rumination ;rumination response ;anxiety level ;degree of depression remission ;insomnia severity ;affective state;daily emotional states ;psychophysiological measures (HRV, SCL, SCR, ACC, GYRO);family socio-economic status ;suicidal thoughts ; | — |
Secondary
| Measure | Time frame |
|---|---|
| self-efficiency ;self-efficiency of emotion regulation ;response inhibition/ cognitive control ;cognitive flexibility ;emotional working memory ;attentional control ability ;interoceptive awareness ;mental flexibility ;sensitivity to reward and punishment ;life events ;intolerance of uncertainty;pleasure experience ;behavioral inhibiton/activation ;childhood trauma;personality traits;systemic family dynamics; | — |
Countries
China
Contacts
Public ContactChaogan Yan
Institute of Psychology, Chinese Academy of Sciences
Outcome results
None listed