obstructive sleep apnea syndrome
Conditions
Interventions
Experimental group:Propofol was administered at a constant rate of 7-10 mg/kg/h and remifentanil was administered intravenously at 0.3-0.5 µg/kg/min to maintain analgesia.
Control group :Continuous inhalation of sevoflurane during the operation, concentration control 2-4%, oxygen flow control 2 L/min, maintenance of end-expiratory partial pressure of carbon dioxide 35-4
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Children scheduled to undergo adenotonsillectomy due to obstructive sleep apnoea; 2. Aged 2-12 years; 3. American Society of Anesthesiologists (ASA) assessment grade II or III.
Exclusion criteria
Exclusion criteria: 1. Premature birth and growth retardation; 2. BMI > 25 kg/m2; 3. Gastrointestinal diseases or any other serious mental or physical illness; 4. A history of oral prebiotics, probiotics or any other similar medication within the two months prior to stool sampling; 5. Use of nitrous oxide or other inhalants (except sevoflurane) during surgery; 6. Allergic to propofol or sevoflurane; 7. If the patient/parent/legal guardian shows strong preference for anesthesia technique, consideration bias will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute postoperative pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of acute postoperative pain;Extubation time;Time to meet the cirteria of leave PACU;Incidence of postoperative pain;Degree of postoperative pain;Incidence of chronic postoperative pain;Degree of chronic postoperative pain;blood pressure;Heart rate;bispectral index;injury index, NOX; | — |
Countries
China
Contacts
Public ContactBilian Li
Guangzhou Women and Children's Medical Center
Outcome results
None listed