epilepsy
Conditions
Interventions
PFO closure group:patent foramen ovale closure and antiepileptic drugs
Epilepsy control group:NA
Healthy control:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for epilepsy of the International Anti epileptic Alliance (ILAE) (2014 version) and the diagnostic criteria for refractory epilepsy (2010 version); (2) The frequency of epileptic seizures was = 1 time per three month; (3) Aged 18-60 years old; (4) The patient agreed to the treatment of this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) The study participants have cognitive impairment, with an MMSE score of = 23; (2)Severe mental illness or substance abuse; (3) Pregnancy, lactation or pregnancy planning within one year;(4) Participating in other interventional clinical trials; (5)Patients judged by the investigator to be unfit for clinical trials; (6) Presence of metals in the body or other contraindications for magnetic tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI;MEG;EEG;The average monthly seizure frequency decrease in one year;Duration of seizure attack; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of epilepsy severity;Improvement of epilepsy severity;Degree of depression;Anxiety level; | — |
Countries
China
Contacts
Public ContactChen Lei
West China Hospital, Sichuan University
Outcome results
None listed