Postoperative Delirium
Conditions
Interventions
The intervention group :In the intervention group, subjects will receive an intravenous infusion of S-ketamine following a standard dilution protocol [40mg S-ketamine with 0.9% normal saline to 20ml,
The control group:In the control group, subjects will receive 0.9% saline at 0.1 ml/kg/h. The infusion time was 1 hour, and the mode was constant rate infusion.
After surgery, all subjects will be tra
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient age>=60 years old; 2. Selective total hip or knee replacement surgery under spinal anesthesia; 3. Sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who were in a state of delirium and suffering from mental illness before the start of the experiment; 2. Patients with contraindications to the use of ketamine (such as allergies, intracranial aneurysms, hyperthyroidism, and glaucoma); 3. Patients with severe cardiovascular diseases (such as Grade III hypertension, unstable angina, severe heart valve disease, severe arrhythmia, and severe macrovascular disease); 4. Patients with severe liver and kidney dysfunction (such as Child Pugh score III, creative clearance rate30 kg/m^2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the incidence of POD in the first 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of positive delirium;The onset time and duration of delirium;Delirium severity score;Subtypes of delirium;Pain scores at rest and exercise;Opioid consumption;The time of first analgesia pump compression within 24 hours after surgery;Preoperative baseline and 3 days post-operative Timed Up and Go test;Active range of motion of the affected knee or hip at preoperative baseline and postoperative day 3 ;Barthel index score is at baseline and at day 3 after surgery;Time to discharge criteria;Length of hospital stay;Sleep quality on postoperative day 1 to 3; | — |
Countries
China
Contacts
Public ContactYang Zhao
The Affiliated Hospital of Qingdao University
Outcome results
None listed