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The role and mechanism of MMR/MSI phenotypes in evaluating vaccine benefit in glioblastoma

The role and mechanism of MMR/MSI phenotypes in evaluating vaccine benefit in glioblastoma

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300075786
Enrollment
Unknown
Registered
2023-09-15
Start date
2023-09-15
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glioma

Interventions

Sponsors

Huashan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Samples and clinical information from glioma patients will be collected prospectively All brain tumor patients in Neurosurgery Department of Huashan Hospital Affiliated to Fudan University can be enrolled if they meet all of the following criteria: ?>18 years old, male or female; ?Image diagnosis is glioma; ?Surgery is required; ?The pathological return of the frozen section during the operation was glioma; ?On the basis of ensuring that routine clinical diagnosis and treatment is not affected, a certain amount of fresh biological samples can be used for research; ?Sign informed consent voluntarily. 2) Samples and clinical information of glioma patients will be collected retrospectively ?>18 years old, male or female; ?The pathological diagnosis was glioma; ?On the basis of ensuring that routine clinical diagnosis is not affected, it is advisable to carry out immunohistochemical staining of paraffin sections (2 pieces); ?The patients voluntarily joined the study.

Exclusion criteria

Exclusion criteria: 1) Samples and clinical information from glioma patients will be collected prospectively Patients who meet any of the following criteria will not be enrolled in this study: ?The pathological return of the frozen section during the operation was not consistent with glioma; ?After removing the samples required for normal diagnosis and treatment, the remaining sample size is not enough for research; ?Patients are unwilling to join the study. 2) Samples and clinical information of glioma patients will be collected retrospectively Patients who meet any of the following criteria will not be enrolled in this study: ?Wax blocks stored for too long and moldy; ?Unwilling to participate in the study.

Design outcomes

Primary

MeasureTime frame
MMR/MSI phenotype;

Countries

China

Contacts

Public ContactDi Chen

Huashan Hospital, Fudan University

chendichina@163.com+86 158 0176 6264

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026