Major depressive disorder
Conditions
Interventions
Routine rTMS intervention group:The intervention target of rTMS was determined by the empirical "5cm rule". The hot spot in the left movement area was moved forward by 5cm as the site of the left DLPF
Precision rTMS intervention group:Magnetic resonance scanning was used for accurate positioning, and the [-44,36,20] position of MNI coordinates was selected as the cortical precise target to be inter
Pseudo-stimulus rTMS intervention group:The appearance and sound of the pseudo-coil and the treatment coil are difficult to distinguish, but the actual magnetic stimulation intensity is far below the
Sponsors
Shanghai Pudong New Area Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for depression in ICD-10 (outpatient patients need to be clinically diagnosed by two physicians with a title of attending or above); 2. Agree to receive rTMS treatment; First or recurrent, the duration of the attack =3 years; 3, age 18-65 years old; Junior high school or above; 4. This attack failed to respond to a full dose of SSRI antidepressant for 4 weeks or was intolerant to at least one antidepressant; 5. Score of HAMD-17 item scale =17 points; 6. The dose of medication did not change in the first 2 weeks of enrollment.
Exclusion criteria
Exclusion criteria: 1within the last three months, drug or alcohol dependence and other effects on cognitive function; 2, have serious physical diseases, cardiac pacemakers or implanted drug pumps; 3, have serious negative ideas and behaviors; 4, pregnant women; 5. Treatment with ECT is ineffective; 6, any neurological diseases, including intracranial injury, epilepsy, Parkinson's disease, etc. 7. There are metal implants in the skull; Use of anticonvulsant drugs; 8. Use of benzodiazepines within 12 hours and alcohol within 8 hours prior to the cognitive test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17;the THINC-it tool; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA-14;Dimensional Anhedonia Rating Scale;Pittsburgh Sleep Quality Index; | — |
Countries
China
Contacts
Public ContactZhu Na
Shanghai Pudong New Area Mental Health Center
Outcome results
None listed