end-stage knee disease
Conditions
Interventions
observation group:Various concentrations of ropivacaine and Dexmedetomidine
control group:Various concentrations of ropivacaine
Sponsors
Hai'an Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patient with end-stage knee disease, scheduled to undergo total knee arthroplasty; 2.Patients aged 50 to 80years; 3.The American Society of Anesthesiologists(ASA)graded ?-? with no other medical diseas; 4.BMI:18-30kg/m.
Exclusion criteria
Exclusion criteria: 1.unplanned emergency surgery; 2.severe cardiac insufficiency or serious lung diseases; 3.patients with severe cardiopulmonary liver and kidney dysfunction 4.mental illness or diminished cognitive function, or taking long-term antipsychoticor related drugs, or drug users; 5.allergies or contraindications to any of the study drugs; 6.Patients who had contraindications to nerve block, and can-not tolerate a phrenic nerve block. 7. long-standing pain or neuropathic pain; 8. taking long-term analgesic drugs or Alcoholabuse disorder ; 9.illiterate, or understand the study scoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Half effective concentration, 95% effective concentration;Pain conditions(VAS Scoring);EC50 by sequential approach; | — |
Secondary
| Measure | Time frame |
|---|---|
| the perioperative conditions ;Postoperative Situation and the wake-up period conditions ;adverse reactions;vital signs;Postoperative analgesia and remedial analgesia;nerve block-related conditions;Prognosis of the studied patients; | — |
Countries
China
Contacts
Public ContactHaixia Lu
Hai'an Hospital of Traditional Chinese Medicine
Outcome results
None listed