Endocrine hypertension
Conditions
Interventions
Normal high value group/New onset hypertension group/Refractory hypertension group/Good blood pressure control group:N/A
Sponsors
Beijing Children's Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age 18 or older, informed consent, and meets one of the following conditions: 1.Patients who are newly diagnosed with hypertension (according to the Chinese Guidelines for the Prevention and Treatment of Hypertension, 2018 revised edition) and have not used antihypertensive drugs, with clinic systolic blood pressure (SBP) = 140 mmHg and/or diastolic blood pressure (DBP) = 90 mmHg; 2.Patients with well-controlled blood pressure who voluntarily agree to participate; 3.Patients with refractory hypertension who have taken three antihypertensive drugs at a tolerable and reasonable dose, including a thiazide diuretic, for at least 4 weeks and still have blood pressure values above the target level in the clinic and outside the clinic (including home blood pressure or ambulatory blood pressure monitoring), or patients who need at least 4 drugs to achieve blood pressure control; 4.Patients with high-normal blood pressure, with clinic SBP 120-139 mmHg and/or DBP 80-89 mmHg, and have one of the following high-risk factors: overweight, obesity, alcohol consumption, abnormal blood glucose, and abnormal triglycerides.
Exclusion criteria
Exclusion criteria: 1.Patients with severe liver dysfunction, congenital heart disease, malignant tumors, and severe infections; 2.Patients with severe mental illness or cognitive impairment; 3.Patients who are difficult to follow-up or cannot provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of endocrine hypertension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Aldosterone;Angiotensin I;Plasma renin activity;Dopamine;Adrenaline;Noradrenaline;Hydrocortisone;11- deoxycortisol;21- deoxycortisol;Corticosterone;Blood potassium;Blood routine;Liver function;Renal function;Imaging indicators;Inflammatory cytokine; | — |
Countries
China
Contacts
Public ContactAihua Hu
Beijing Children's Hospital, Capital Medical University
Outcome results
None listed