Melasma
Conditions
Interventions
1064nm Q-switched Nd: YAD laser:Q-switched laser (Spectra, Korea), wavelength 1064nm, 6-8mm spot size, 1.2-1.6J/cm2, and the end reaction was mild skin erythema.
532nm Q-switched Nd: YAD laser:Q-switched laser (Spectra, Korea), wavelength 532nm, 6-8mm spot size, 0.1-0.15J/cm2, and the end reaction was mild skin erythema.
Sponsors
Zhongda Hospital, Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: According to the "Chinese Expert Consensus on the Treatment of melasma (2021)", patients with facial melasma diagnosed based on medical history and typical clinical manifestations, aged = 18 years and <75 years, who could understand and voluntarily sign written informed consent, and could complete treatment and follow-up as required.
Exclusion criteria
Exclusion criteria: Pregnancy, lactation, or any hormone therapy; photosensitive medication within 3 months before the study; topical corticosteroid use within 1 month before the study; treatment for melasma (including topical hydroquinone, retinoic acid, kojic acid, azelaic acid, oral tranexamic acid, topical laser or intense pulsed light therapy) within 1 month before the study; excessive photosensitivity to normal sunlight; connective tissue disease, thyroid dysfunction, anxiety and depression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melasma area severity index, MASI;Melasma index;Erythema index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Dermoscopic Score (TDS);Dermal thickness;dermal density;the thickness of subepidermal low-echogenic band;Alexiades-Armenakas ;Dermoscopic Photoaging Scale; | — |
Countries
China
Contacts
Public ContactQianya Su
Zhongda Hospital, Affiliated to Southeast University
Outcome results
None listed