breast cancer
Conditions
Interventions
Control Group:Conventional anesthesia plan
Esketamine Group:Esketamine was used to anesthesia induce ,maintain and postoperative analgesia
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1). Aged >= 18 years; 2). ASA grade I-III; 3). Patients undergoing elective breast cancer surgery;
Exclusion criteria
Exclusion criteria: 1). Reoperation after recurrence; 2). Cognitive impairment or difficulty in communication; 3). Severe circulatory andrespiratory diseases such as severe coronary heart disease and COPD; 4). Endocrine diseases such as pituitary adenomas, severe diabetes, cortisol syndrome, pheochromocytoma, etc.; 5). Mental and psychological diseases: such as schizophrenia, history of chronic analgesics, alcoholism, opioid dependence; 6). Patient refused to participate in this study; 7). Allergy to esketamine; 8). Body mass index > 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD depression scale score on the 3rd day after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD depression scale scores on the 1st, 5th, 7th, 14th, 30th day after operation;Score of QoR-15 scale;Numerical Rating Scale (NRS) pain score;Consumption of analgesics;Characteristic changes of electroencephalogram;Adverse reaction;Hospitalization time;Hospitalization expenses;Postanesthesia care unit stay time; | — |
Countries
China
Contacts
Public ContactChen Lijian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed