Ventilator-associated pneumonia
Conditions
Interventions
Experimental group:The secretions of the lower respiratory tract of patients were collected for bacterial culture to obtain the information of major multi-drug-resistant pathogens. The sensitivity tes
Sponsors
Southern University of Science and Technology Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 95 Years
Inclusion criteria
Inclusion criteria: (1) Patients with multi-drug resistant bacterial infection (based on the drug sensitivity test results of our hospital or a third or higher hospital), except patients aged 0-95 with tumor and other diseases in the terminal stage who cannot benefit from treatment; (2) Pathogens infected by patients should meet one of the following conditions: 1) Pathogens resistant to key antibiotics (see the 12 superbugs defined by WHO 2017) 2) Pathogenic bacteria are sensitive to key antibiotics in vitro, but the antibiotic treatment is ineffective or ineffective (temperature, airway secretions, imaging, inflammation indicators and other indicators do not improve after 1 week of clinical use) 3) Limited use of critical sensitive antibiotics (patients with organ function impairment or allergy to antibiotics) (3) At least one phage matching with resistant bacteria can be screened (4) It can be administered by external application, spraying, atomizing inhalation, perfusion, local injection or catheter (5) The subjects and their family members (or guardians) fully read, understand and sign the informed consent
Exclusion criteria
Exclusion criteria: (1) Bacterial infections can be effectively controlled by antibiotic treatment (2) There is no effective way of administration other than intravenous administration (3) Exceeding the medical service load of the unit (4) Patients determined by the investigators to be unsuitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood test index and imaging results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation parameters; | — |
Countries
China
Contacts
Public ContactYu Jialin
Hospital of Southern University of Science and Technology
Outcome results
None listed