Study on the effectiveness and safety of high tidal volume synchronous inspiratory oscillation on airway clearance

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075699

Enrollment

Unknown

Registered

2023-09-13

Start date

2023-09-15

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe pneumonia

Interventions

high tidal volume synchronous inspiratory oscillation group (Group A):Observation of original ventilator parameters 1h+ high tidal volume synchronous inspiratory oscillation mode intervention 1h

high tidal volume group (Group B):Observation of original ventilator parameters 1h+ high tidal volume mode intervention 1h

No-intervention group (Group C):Observation of original ventilator parameters 2h

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age > 18 years old; 2. Patients with tracheotomy or tracheal intubation; 3. CT/ chest X-ray suggests pulmonary infection, atelectasis, mucus plug, etc.

Exclusion criteria

Exclusion criteria: 1. Undrained pneumothorax or pleural effusion; 2. Acute pulmonary edema; 3. Severe bronchospasm; 4. Pulmonary bulla; 5. Acute respiratory distress syndrome (ARDS); 6. Tumors or lung tumors that block the airway; 7. Bronchopleural fistula; 8, hemoptysis, coagulation disorders; 9. Hemodynamic instability (MAP 20mmHg.

Design outcomes

Primary

Measure	Time frame
sputum wet weight;sputum volume;	—

Secondary

Measure	Time frame
heart rate;respiratory rate;blood pressure;arterial blood gas analysis;esophageal pressure;intragastric pressure;diaphragm EMG;static lung compliance;diaphragm muscle mobility;	—

Countries

China

Contacts

Public ContactZeguang Zheng

The First Affiliated Hospital of Guangzhou Medical University

zheng862080@139.com+86 189 2886 8242

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026