none
Conditions
Interventions
Placebo group:Daily intake of placebo during the trial
Lactobacillus casei Zhang powder group:Lactobacillus casei Zhang powder was ingested daily during the trial period
Lactobacillus casei Zhang, Lactobacillus plantarum HUN082 and other complex probiotic powder groups:Daily intake of probiotic complex powder during the trial period
Sponsors
Haikou City People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: ? After passing the serum biochemical test, the physiological and biochemical indicators meet the following standards: a. Serum immunoglobulin IgA was in the range of 1.0-4.2 g/L; b. Serum immunoglobulin IgE was in the range of 0~360 IU/mL; c. Serum immunoglobulin IgG was in the range of 8.6~17.4 g/L; d. Serum total cholesterol was in the range of 3.1 to 5.7 mmol/L; e. Serum triglycerides were in the range of 0.4 to 1.7 mmol/L; f. Serum high density lipoprotein cholesterol in the range of 1.0 to 1.6 mmol/L; g. Serum low density lipoprotein cholesterol was in the range of 0 to 3.3.37 mmol/L; h. The fasting blood glucose in serum was in the range of 3.9~6.1 mg/L; i. eosinophils were 0~0.06; j. basophils were 0.02~0.52 ?Age > 50 years old Chinese, male or female ? Sign informed consent ? No antibiotic use within three months
Exclusion criteria
Exclusion criteria: ? History and family history of colon cancer, celiac disease and inflammatory bowel; ? A colo-colonoscopy has confirmed organic intestinal disease; ? Recent pregnant women (including men and women), pregnant or lactating women; ? Allergic to the sample or ingredient; ? have taken probiotics and probiotic-related preparations in the past 2 weeks; ? People who have taken anti-anxiety, anti-depression and other psychiatric drugs in the past 2 weeks; 7 Have been diagnosed with myocardial infarction, cerebral infarction, malignant tumor and other serious diseases that researchers believe are not suitable for inclusion; Subjects with major mental disorders, difficulty in controlling their actions, unable to cooperate; ? Subjects who are illiterate, unable to understand informed consent, and unable to sign informed consent by themselves.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IgA;IgE;IgG;cholesterol;triglyceride;high density lipoprotein cholesterol;low density lipoprotein cholesterin;eosinophils;basophils; | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of gut microbiota;Adverse reactions; | — |
Countries
China
Contacts
Public ContactWei Lu
Haikou City People's Hospital
Outcome results
None listed