Alzheimer’s disease
Conditions
Interventions
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Cohort 1 (AD group. n=150) 1) Age greater than 50 and less than 85 years old; 2) Diagnosed with AD according to IWG-2 criteria; 3) Did not receive disease-modifying therapy before exhaled breath sample collection; 4) Patients have been fully informed, agreed to participate in the program, and are expected to complete the examination related to the program. (2) Cohort 2 (non-AD cognitive impairment group, n=150) 1) Age greater than 50 and less than 85 years old; 2) Cognitive impairment due to other neurological diseases, including vascular cognitive impairment, frontotemporal lobar degeneration, and dementia with Lewy bodies; 3) Patients have been fully informed, agreed to participate in the program, and are expected to complete the examination related to the program. (3) Cohort 3 (Cognitively unimpaired healthy control group, n=150) 1) Age greater than 50 and less than 85 years old; 2) Having no subjective cognitive decline complaints and normal performance in objective neuropsychological tests
Exclusion criteria
Exclusion criteria: 1) Need respiratory support (oxygen, non-invasive ventilator, etc.); 2) Unable to obtain sufficient expired air due to respiratory restriction 3) Breastfeeding or pregnant women; 4) Poor compliance, unwillingness to accept the examination, or unwillingness to complete the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the mass-to-charge ratios of volatile organic compounds (VOCs) in exhaled breath from subjects.; | — |
Countries
China
Contacts
Public ContactNan Zhang
Tianjin Medical University General Hospital
Outcome results
None listed