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The study of resting-state functional magnetic resonance imaging in patients with knee osteoarthritis based on central hyperalgesia

The study of resting-state functional magnetic resonance imaging in patients with knee osteoarthritis based on central hyperalgesia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300075649
Enrollment
Unknown
Registered
2023-09-11
Start date
2023-10-01
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

KOA group (Clinical data, central sensitization scale ( CSI ), visual analogue pain score ( VAS ), Western Ontario McMaster University Osteoarthritis Index ( WOMAC ) and radiological indicators were c
HC group (Clinical data, central sensitization scale ( CSI ), visual analogue pain score ( VAS ), Western Ontario McMaster University Osteoarthritis Index ( WOMAC ) and radiological indicators were co

Sponsors

Gansu Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 70 Years

Inclusion criteria

Inclusion criteria: The KOA group meets the diagnostic criteria of KOA and has typical clinical symptoms. KOA group and HC group included patients were required: Han nationality, age 45-70 years old, gender unlimited; education level above junior high school; right handed; at least 2 months did not take psychotropic drugs.

Exclusion criteria

Exclusion criteria: Organic diseases of the central nervous system ; mental and psychological history combined with somatization symptoms; a history of serious medical diseases; history of head trauma; history of trauma surgery; history of drug abuse or substance dependence; people with visual and hearing impairment ; any magnetic resonance imaging (MRI) contraindications.

Design outcomes

Primary

MeasureTime frame
Low frequency fluctuation amplitude;Regional homogeneity;Brain functional connectivity ;Visual Analogue Scale ;Western Ontario McMaster University Osteoarthritis Index;

Secondary

MeasureTime frame
Central Sensitization Scale;

Countries

China

Contacts

Public ContactHongzhang Guo

Gansu Provincial Hospital

g_hz@163.com+86 187 9319 1010

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026