recurrent miscarriage
Conditions
Interventions
Recurrent miscarriage group:Pregnancy Care Management
Healthy menstruating women group:none
Healthy pregnancy group:none
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Recurrent miscarriage group: (i) presence of =2 pregnancy losses from conception to 24 weeks of gestation, (ii) 18 years = age = 40 years; Healthy menstruating women group: (i) no adverse maternal history, (ii) =1 delivery, (iii) 18 years = age = 40 years; Healthy pregnancy controls: (i) gestational status, (ii) Complete maternity information, (iii) 18 years = age = 40 years;
Exclusion criteria
Exclusion criteria: Recurrent abortion group: (i) history of thrombosis or bleeding disorders; (ii) acute infections, surgery and anticoagulant administration in the last 2 months. Healthy menstruating women group: (i) history of smoking; (ii) history of hypertension, diabetes mellitus, heart disease, chronic kidney disease, liver disease, neoplasm, and immune system disorders prior to pregnancy; (iii) acute and chronic hematologic disorders prior to or during pregnancy; (iv) anticoagulant or antiplatelet medications prior to enrollment; (v) history of recent traumas and surgeries; (vi) patients with a definitive diagnosis of antiphospholipid syndrome and a predisposition to thrombosis; (vii) a history of recurrent miscarriages; (viii) a history of thrombotic or hemorrhagic disorders; and (ix) healthy participants presenting in the second trimester with hypertensive disorders of pregnancy (HDP). Healthy pregnancy group: (i) history of smoking; (ii) history of hypertension, diabetes mellitus, heart disease, chronic kidney disease, liver disease, neoplasm, and immune system disorders prior to pregnancy; (iii) acute and chronic hematologic disorders prior to or during pregnancy; (iv) anticoagulant or antiplatelet medications prior to enrollment; (v) history of recent traumas and surgeries; (vi) patients with a definitive diagnosis of antiphospholipid syndrome and a predisposition to thrombosis; (vii) a history of recurrent miscarriages; (viii) a history of thrombotic or hemorrhagic disorders; and (ix) healthy participants presenting in the second trimester with hypertensive disorders of pregnancy (HDP).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| thrombin–antithrombin III complex (TAT);plasmin-a2-plasmininhibitor complex (PIC);thrombomodulin (TM);tissue plasminogen activator–inhibitor complex(t-PAIC); | — |
Countries
China
Contacts
Public ContactWang Fang
Lanzhou University Second Hospital
Outcome results
None listed