Generalized Anxiety Disorder
Conditions
Interventions
50ms:The right parietal lobe was stimulated first, followed by the right DLPFC. Coil A is stimulated 50ms earlier than coil B. Stimulation frequency:1Hz
Stimulation intensity: 90% of the resting motor threshold
1500 pulses/session
consecutive treatment of 14 days.
100ms:The right parietal lobe was stimulated first, followed by the right DLPFC. Coil A is stimulated 100ms earlier than coil B. Stimulation frequency:1Hz
150ms:The right parietal lobe was stimulated first, followed by the right DLPFC. Coil A is stimulated 150ms earlier than coil B. Stimulation frequency:1Hz
P4 group:Stimulation site is P4
Stimulation frequency:1Hz
Sham group:The stimulation parameters set by the sham group do not produce magnetic pulse output, only magnetic stimulation frequency. The sham-coil and the active coil are required to have the same a
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.The diagnosis of generalized anxiety disorder was confirmed according to Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V); 2. Aged between 18-65 years old; 3. Hamilton Anxiety Scale (HAMA) score >14; 4. Patients who have taken anti-anxiety drugs do not need to stop taking them, but the type, method and dosage of medication remain unchanged four weeks before treatment, during treatment and two months after treatment; 5. No positive findings were found in nervous system physical examination; 6. All patients were right-handed.
Exclusion criteria
Exclusion criteria: 1. Exclude other types of anxiety diagnosed according to DSM-V, such as panic disorder, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, agoraphobia, and specific phobia; 2. Patients with Hamilton Depression Scale (HAMD) score >17 were excluded; 3. Exclude secondary anxiety caused by other organic diseases, such as secondary anxiety induced by serious liver, kidney and heart diseases, serious trauma, etc.; 4. Patients with a history of brain surgery and epilepsy were excluded; 5, Exclude changes in drug dosage during treatment; 6, Exclude metal foreign bodies in the body, such as pacemakers, DBS therapeutic devices, stents and other patients; 7. Exclude pregnant and nursing patients; 8. Those who had suffered from other mental illness or substance/drug abuse or dependence in the 6 months prior to enrollment were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After the end of treatment on the 14th day, the reduced score of the HAMA scale compared to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety severity assessment;Depression severity assessment;insomnia severity assessment; | — |
Countries
China
Contacts
Public ContactYuping Wang
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Outcome results
None listed