Atopic dermatitis
Conditions
Interventions
Placebo group:Solid beverage without Lactobacillus reuteri
Lactobacillus reuteri Fn041 solid beverage group 1:Lactobacillus reuteri Fn041 1×10^9 CFU/d
Lactobacillus reuteri Fn041 solid beverage group 2:Lactobacillus reuteri Fn041 5×10^9 CFU/d
Lactobacillus reuteri Fn041 solid beverage group 3:Lactobacillus reuteri Fn041 1×10^10 CFU/d
Sponsors
Wuxi Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
16 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1: the mother or the father of the fetus or the previous child of the couple diagnosed with allergic diseases (such as food allergies or eczema/atopic dermatitis or asthma or allergic rhinitis) 2: healthy pregnant woman (14th to 16th weeks of pregnancy)
Exclusion criteria
Exclusion criteria: 1: pregnant woman under 16 2: multiple pregnancies 3: known fetal abnormalities 4: maternal immune deficiency or orally taking immunosuppressive drugs 5: suffering from heart valve disease or immunodeficiency 6: using antibiotics within one month 7: with a history of transplantation or HIV 8: long term continuous use or ongoing use or intending to use probiotics before admission 9: external fertilization pregnancy 10: previously participated in researches 11: deemed unsuitable for inclusion in the study due to any other medical reasons 12: with gestational diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative incidence of AD within two years of age; | — |
Secondary
| Measure | Time frame |
|---|---|
| TGF-ß, IL-10, IL-12,IL-13, IL-4 and IgE of the cord blood;Lactobacillus reuteri content in breast milk;Lactobacillus reuterii content in infant feces; | — |
Countries
China
Contacts
Public ContactRenqiang Yu; Xiaohui Cao
Wuxi Maternity and Child Health Care Hospital
Outcome results
None listed