kidney cancer
Conditions
Interventions
Intervention group:MR-guided adaptive radiotherapy
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female, age =18 years old; 2. Pathologically diagnosed with renal cell carcinoma, or imaging findings consistent with typical presentation of renal cell carcinoma; 3. Primary renal tumor, or intra-renal recurrence after partial nephrectomy; 4. Life expectancy =2 years; 5. ECOG score 0-2; 6. Active treatment is warranted; 7. Non-surgical candidate, including surgically resectable or unable to tolerate surgery;
Exclusion criteria
Exclusion criteria: 1. Contraindications for MRI examination; 2. Creatinine clearance <30mL/min; 3. Currently receiving anti-angiogenic targeted therapy; 4. Pregnant, planning for pregnancy, or lactating women; 5. Prior radiotherapy to the primary tumor; 6. Poor control of concomitant disease, under which radiotherapy may cause deterioration of disease and becomes life-threatening; 7. Deemed unsuitable for inclusion by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate;Progression-free survival;Distant metastasis-free survival;Overall survival;renal function;radiotherapy-related adverse event; | — |
Countries
China
Contacts
Public ContactLiru He
Sun Yat-sen University Cancer Center
Outcome results
None listed